Exosomes are nanosize microvesicles shed by cells into the blood and other body fluids as a way of cell-to-cell communication. Exosomes are particles of ~50-100nm in diameter with a bi-lipid membrane and contain significant amounts of RNAs, proteins and lipids. Exosomes are rich in disease-specific biomarkers and can be isolated from liquid samples such as plasma and serum. Abundant plasma proteins like albumin can introduce noise in diagnostic tests. Using exosome enriched samples, this can easily be avoided. At ACS Biomarker we use a validated in-house method to obtain exosome enriched samples.